The purpose of this paper is to discuss the significance of Compassion Fatigue (CF) and its effects in the lives of caregivers. A caregiver is defined by dictionary. com as an individual, such as a physician, nurse, or social worker, who assists in the identification, prevention, or treatment of an illness or disability (dictionary. com). Caregivers may also include family members, friends or neighbors who voluntarily have accepted responsibility for looking after a vulnerable neighbor or relative. For the purpose of this paper, the primary caregivers discussed will be nurses.Most nurses chose nursing as a career because they have the desire to both help people and provide care for patients with physical, mental, emotional, and spiritual needs. Having this desire puts nurses at risk for suffering from CF. CF can affect nurses in many areas such as physically, emotionally, in job performance, as well as their attitude toward the work environment, coworkers, and their patients.